Sex-disaggregated analysis of the injury patterns, outcome data and trapped status of major trauma pattents injured in motor vehicles collisions: a prespecified analysis of the UK trauma registry (TARN)

Sex-disaggregated analysis of the injury patterns, outcome data and trapped status of major trauma pattents injured in motor vehicles collisions: a prespecified analysis of the UK trauma registry (TARN)

Tim Nutbeam, Lauren Weekes, Shirin Heidari, Rob Fenwick, Omar Bouamra, Jason Smith, Willem Stassen

BMJ Open – April 6, 2022

Objectives. To identify the differences between women and men in the probability of entrapment, frequency of injury and outcomes following a motor vehicle collision. Publishing sex-disaggregated data, understanding differential patterns and exploring the reasons for these will assist with ensuring equity of outcomes especially in respect to triage, rescue and treatment of all patients.

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Resolving sex and gender bias in COVID-19 vaccines R&D and beyond

Resolving sex and gender bias in COVID-19 vaccines R&D and beyond

Lavanya Vijayasingham, Shirin Heidari, Jean Munro, Saad Omer, Noni MacDonald

Human Vaccines & Immunotherapeutics – January 25, 2022

The influence of sex and gender in immune response and vaccine outcomes is established in many disease areas, including in COVID-19. Yet, there are notable gaps in the consideration of sex and gender in the analysis and reporting of COVID-19 vaccines clinical trial data. The push for stronger sex and gender integration in vaccines science should be championed by all researchers and stakeholders across the R&D and access ecosystem – not just gender experts.

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Gender perspective in COVID-19. SESPAS Report 2022

Gender perspective in COVID-19. SESPAS Report 2022

Shirin Heidari

Gaceta Sanitaria – January, 2022

We failed to adequately launch a gender transformative response to COVID-19 pandemic, data by sex on a variety of indicators for most countries are hard to find. Some symptoms reported as common of COVID-19 infection, are more prominent in men, while others are more prominent in women, one cannot with certainty exclude that some of the differences observed could be due to gender bias in the management of cases in health services. The gender implications of the pandemic reach wide and far. Inequalities can be further aggravated as sex and gender intersect with other axes of inequality.

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Considerations of sex and gender dimensions by research ethics committees: a scoping review

Considerations of sex and gender dimensions by research ethics committees: a scoping review

Abha Saxena, Emily Lasher, Claire Somerville, Shirin Heidari

OXFORD Academic, International Health – January 18, 2022

Despite a growing consensus on the importance of integrating sex and gender in health research, research across disciplines continues to be conducted and reported without a gender focus. Research ethics committees (RECs) can play a particularly powerful role in identifying the gender gaps at an early stage of the development of research protocols. Their role is missing in the dialogue related to improving gender awareness and analysis in health research. A scoping review was conducted to examine the extent to which RECs discuss and consider the inclusion and analysis of sex and gender in health research and to examine the literature regarding the gender balance of RECs. The limited literature around gender and research ethics reveals the power and potential of RECs to ensure that gender dimensions are thoughtfully included in health research, and sheds light on the gaps that exist. These include an under-representation of women on RECs, a lack of awareness of the importance of gender-related aspects in health research and a paucity of gender-related training to RECs. Guidelines such as the Sex and Gender Equity in Research guidelines are required for RECs to strengthen the ways in which health research is gendered from conception of a research protocol to its publication.

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A Systematic Review of the Sex and Gender Reporting in COVID-19 Clinical Trials

A Systematic Review of the Sex and Gender Reporting in COVID-19 Clinical Trials

Shirin Heidari, Alice Palmer-Ross, Tracey Goodman

Vaccines – November 15, 2021

Sex and gender have implications for COVID-19 vaccine efficacy and adverse effects from the vaccine. As vaccination is one of the key responses to the COVID-19 pandemic, it is vital that sex and gender differences be acknowledged, measured, and analysed in clinical research. Here, we systematically review published COVID-19 vaccine trials, both interventional and observational, to assess the quality of reporting of sex and gender.

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Fifth anniversary of the Sex And Gender Equity in Research (SAGER) guidelines: taking stock and looking ahead

Fifth anniversary of the Sex And Gender Equity in Research (SAGER) guidelines: taking stock and looking ahead

Sanne A E Peters, Thomas F Babor, Robyn N Norton, Janine A Clayton, Pavel V Ovseiko, Cara Tannenbaum, Shirin Heidari

BMJ Global Health – November 8, 2021

This year marks the fifth anniversary of the publication of the Sex And Gender Equity in Research (SAGER) guidelines, which provide recommendations to authors, journal editors, peer-reviewers and publishers for ensuring that sex and gender considerations are appropriately reported in the scholarly literature. The guidelines were developed in recognition of the persistent sex and gender gaps in research across disciplines, especially in health and biomedical research. At the time of development, there was notable resistance to implement sex and gender policies, reflecting a lack of awareness of the importance of sex and gender as critical determinants of health and well-being.

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