A Systematic Review of the Sex and Gender Reporting in COVID-19 Clinical Trials

Shirin Heidari, Alice Palmer-Ross, Tracey Goodman

Vaccines – November 15, 2021

Sex and gender have implications for COVID-19 vaccine efficacy and adverse effects from the vaccine. As vaccination is one of the key responses to the COVID-19 pandemic, it is vital that sex and gender differences be acknowledged, measured, and analysed in clinical research. Here, we systematically review published COVID-19 vaccine trials, both interventional and observational, to assess the quality of reporting of sex and gender.

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